Registration Dossier

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: observation time 7 days, short documentation, low dose 50 mg

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Principles of method if other than guideline:
1 male and 1 female New Zealand white rabbit, 50 mg/rabbit was applied into the conjunctival sac of one eye of each rabbit, observation time: 7 days, evaluation according Draize
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetraethylammonium heptadecafluorooctanesulphonate
EC Number:
260-375-3
EC Name:
Tetraethylammonium heptadecafluorooctanesulphonate
Cas Number:
56773-42-3
Molecular formula:
C8H20N.C8F17O3S
IUPAC Name:
N,N,N-triethylethanaminium 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonate
Details on test material:
no data

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
7 days
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
2

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24, 48, 120 h
Score:
0
Max. score:
4
Reversibility:
other: not applicable (score = 0 at any time point)
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24, 48, 120 h
Score:
0
Max. score:
2
Reversibility:
other: not applicable (score = 0 at any time point)
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24, 48 h
Score:
1
Max. score:
3
Reversibility:
fully reversible within: 5 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24, 48, 120 h
Score:
0
Max. score:
4
Reversibility:
other: not applicable (score = 0 at any time point)
Other effects:
no data

Any other information on results incl. tables

A slight reddening for a short term was caused by the test substance due to a mechanical irritation.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Executive summary:

2 white New zealand rabbits received a dose of 50 mg/animals of the test substance in the conjunctival sac of one eye each. Postexposure period was 7 days.

The test substance was not irritating (a slight reddening for a short term was caused by the test substance due to mechanical irritation)