Registration Dossier

Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)
Cross-reference
Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
test procedure similar to OECD 105
Reason / purpose for cross-reference:
reference to same study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
modified taking into account the very low water solubility of the test substances
Principles of method if other than guideline:
The method for the determination and analytical investigation is according to the method that was agreed upon at the "Analytical Experts Meeting" of ETAD (Basel) on January 12, 2005.
Type of method:
flask method
Water solubility:
0.19 mg/L
Temp.:
22 °C
pH:
ca. 7
Remarks on result:
other: The determination of water solubility was conducted at ambient temperature (22-23 °C)
Details on results:
The value above represents the mean from three determinations (sigma=0.02). See below for indidividual results.

Individual results:

 

Absorption

(d = 10 cm)

mg/L

a1

0.0942

0.18

a2

0.0986

0.19

a3

0.1076

0.21

 

Conclusions:
The test substance has a water solubility of 0.19 mg/L.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: ETAD Analytical expert group
Principles of method if other than guideline:
Determination of n-octanol solubility.
The analytical method for the determination is in agreement with the method that was agreed upon at the Analytical Experts Meeting of ETAD (Basel) on January 12, 2005.

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl 5-[[1-[[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino]carbonyl]-2-oxopropyl]azoterephthalate
EC Number:
249-955-7
EC Name:
Dimethyl 5-[[1-[[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino]carbonyl]-2-oxopropyl]azoterephthalate
Cas Number:
29920-31-8
Molecular formula:
C21H19N5O7
IUPAC Name:
1,3-dimethyl 5-[(E)-2-{2-oxo-1-[(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)carbamoyl]propyl}diazen-1-yl]benzene-1,3-dicarboxylate

Results and discussion

Solubility in organic solvents / fat solubility
Medium:
n-octanol
Solubility:
0.24 mg/L
Temp.:
22 °C
Remarks on result:
other: The determination of the n-octanol solubility was conducted at ambient temperature (22-23 °C).
Details on results:
The value above represents the mean from three determinations (sigma=0.01). See below for indidividual results.

Any other information on results incl. tables

Individual results:

 

Absorption
(d = 10 cm)

mg/L

a1

0.1221

0.23

a2

0.1296

0.25

a3

0.1316

0.25


Applicant's summary and conclusion

Conclusions:
The test substance has an n-octanol solubility of 0.24 mg/L.