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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

No inhibition of respiration of activated sludge was observed up to 100 mg/L the highest tested concentration in an OECD 209 compliant study.

Key value for chemical safety assessment

Additional information

The effect of the test item on bacteria was assessed according to OECD 209 by measuring the micro-organisms respiration rate on a sample of activated sludge during an incubation period of 3 hours.


 EC50- 3h 4-methylthiosemicarbazide > 100mg/L, and NOEC < 5 mg/L


4-methylthiosemicarbazide did not show any effect on the respiration of activated sludge in the conditions of the test up to a concentration of 100 mg/L.