Registration Dossier
Registration Dossier
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EC number: 229-563-2 | CAS number: 6610-29-3
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: 4e: Documentation insufficient for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rabbit eyes were treated twice daily for 20 days with 1 mg per eye.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 4-methylthiosemicarbazide
- EC Number:
- 229-563-2
- EC Name:
- 4-methylthiosemicarbazide
- Cas Number:
- 6610-29-3
- Molecular formula:
- C2H7N3S
- IUPAC Name:
- 1-amino-3-methylthiourea
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: ocular
- Details on exposure:
- Test substance was administered undiluted (crystals).
- Duration of treatment / exposure:
- 4 weeks
- Frequency of treatment:
- twice a day, 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 mg/eye
- No. of animals per sex per dose:
- no data
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Haematological findings:
- no effects observed
- Details on results:
- No clinicals findings, no haematological or biochemical parameters and no anatomo-pathological abnormalities were found. Furthermore, no deaths occured during the study.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
