Registration Dossier
Registration Dossier
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EC number: 939-291-2 | CAS number: 90583-10-1
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Expert judgement combined with experimental data.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Human & Evironmental Health Risk Assessment on ingredients of European household cleaning products. Alkyl Sulphates. Environmental Risk assessment. 07 March 2002
- Author:
- HERA
- Year:
- 2 002
- Bibliographic source:
- http://www.heraproject.com
Materials and methods
- Principles of method if other than guideline:
- No guideline exists for this type of appraisal.
- GLP compliance:
- no
Test material
- Reference substance name:
- Category of alkyl sulfates
- IUPAC Name:
- Category of alkyl sulfates
- Details on test material:
- Various, for details see HERA report and SIDS
Constituent 1
- Radiolabelling:
- other: partly
Test animals
- Species:
- other: human, rat, guinea-pig
- Details on test animals or test system and environmental conditions:
- not applicable
Administration / exposure
- Type of coverage:
- other: Various, for details see HERA report and SIDS
- Vehicle:
- not specified
- Duration of exposure:
- Various, for details see HERA report and SIDS
- Doses:
- Various, for details see HERA report and SIDS
- No. of animals per group:
- Various, for details see HERA report and SIDS
Results and discussion
- Absorption in different matrices:
- Absorption by the percutaneous route is limited, since anionic surfactants tend to bind to the skin surface (Howes, 1975; Black and Howes, 1980). Early studies with isolated human skin were unable to detect penetration of a homologous series of AS, ranging from C8 to C18 (Blank and Gould, 1961). Animal studies confirmed a low level of percutaneous absorption of AS. Less than 0.4% of a 3 μmol dose of 35S-labeled C12AS-Na was percutaneously absorbed in guinea pigs, based on recovery of the radiolabel in urine, faeces and expired air (Prottey and Ferguson, 1975). Studies with rats indicated that pre-washing of the skin with surfactant enhanced AS skin penetration (Black and Howes, 1980).
For consumer exposure, actual dermal absorption is below 1% (Rice, 1977) or very low (Schäfer and Redelmeier, 1996), therefore a default assumption of 1% dermal absorption was taken for deriving the DNEL. Since the dermal absorption decreases with increasing concentration of a solution this percentage can be expanded to workers as a worst case approach.
- Conversion factor human vs. animal skin:
- not applicable
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
