Registration Dossier
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EC number: 248-948-6 | CAS number: 28299-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The long-term toxicity of the substance to Daphnia magna was assessed in a 21-day semi-static test according to the OECD Guideline. Immobility of the parental generation and the number of offspring were assessed. The 21-day NOEC for reproduction was determined to be 0.057 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.057 mg/L
Additional information
ECHAconsiders in a Draft Decision on a Compliance Check that the key study is a non GLP study and has important shortcomings: the test water was not according to the current OECD 211 guideline, filtrated surface water was mixed with discharge of a sewage purification plant, no analytical monitoring was performed and results of two consecutive experiments (one using 4 and one using 3 test concentrations) were combined. However, this study was rated as invalid in a Compliance Check due to several short-comings.
Therefore, a new study on chronic exposure of daphnids with ditolyl ether was conducted. Interestingly, this study came up with a 21 days-NOEC (reproduction) of 0.057 mg/L which is nearly identical with the result of the previous study.
In conclusion, the new study confirmed the originally available data on chronic toxicity to daphnids and the new valid study fills the potential data gap for testing on chronic toxixity to daphnids.
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