Registration Dossier
Registration Dossier
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EC number: 248-948-6 | CAS number: 28299-41-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study according OECD 404
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- 3 white New-Zealand rabbits were treated with 0.5 ml of undiluted test substance. The test item remained under semiocclusion on the skin for 4 hours. Treated animals were inspected for skin effects (erythema, oedema) after removal of patches and after 1, 2, 3 and 7 days. Total observation time was 7 days.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ditolyl ether
- EC Number:
- 248-948-6
- EC Name:
- Ditolyl ether
- Cas Number:
- 28299-41-4
- Molecular formula:
- C14H14O
- IUPAC Name:
- Benzene, 1,1'-oxybis[methyl-
- Details on test material:
- content: 99.1%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- White New Zealand rabbits, weight 2.9 to 3.3 kg; husbandry: standardized conventional conditions in individual stainless steel cages.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Amount: 500 µl
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 7 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm²
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with water
- Time after start of exposure: 4 hours
SCORING SYSTEM: according Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Other effects:
- no data
Any other information on results incl. tables
No data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
Method: 3 white New-Zealand rabbits were treated with 0.5 ml of undiluted test substance. The test item remained under semiocclusion on the skin for 4 hours. Treated animals were inspected for skin effects (erythma, oedema) after removal of patches and after 1, 2, 3 and 7 days. Total observation time was 7 days
Result: slightly irritating to the skin, but not sufficient for classification
Reference: Maertins (Bayer AG), 1989
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