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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP non-guideline, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1955
Report date:
1955

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-chloropropyne
EC Number:
210-856-9
EC Name:
3-chloropropyne
Cas Number:
624-65-7
Molecular formula:
C3H3Cl
IUPAC Name:
3-chloroprop-1-yne
Details on test material:
- Name of test material (as cited in study report): Propargyl chloride

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 5% (low dose), 10% (mid- and high-doses)
Doses:
50, 100, 200, 400 mg/kg bw
No. of animals per sex per dose:
- 50 mg/kg bw: 5 females
- 100 mg/kg bw: 5 females
- 200 mg/kg bw: 4 males and 1 female
- 400 mg/kg bw: 4 males and 1 female
Control animals:
no
Details on study design:
- Duration of observation period following administration: 8 days

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 165 mg/kg bw
Based on:
test mat.
Mortality:
- 50 mg/kg bw: no mortality
- 100 mg/kg bw: 1 of the 5 female animals died
- 200 mg/kg bw: 3 of the 4 male animals and the female animal died
- 400 mg/kg bw: all animals died
Clinical signs:
Clinical signs observed were cramps, heavy gait and nervousness

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information