Registration Dossier
Registration Dossier
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EC number: 208-031-3 | CAS number: 506-30-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- [R]: 3.58E3 mg/kg; Estimation for LD50 for CAS 506-30-9
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 013
- Bibliographic source:
- QSAR Toolbox version 3.1
Materials and methods
- Principles of method if other than guideline:
- The prediction is done using QSAR toolbox version 3.1
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Icosanoic acid
- EC Number:
- 208-031-3
- EC Name:
- Icosanoic acid
- Cas Number:
- 506-30-9
- Molecular formula:
- C20H40O2
- IUPAC Name:
- icosanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Eicosanoic acid
- Molecular formula: C20H40O2
- Molecular weight: 312.53
- Substance type:organic
- Physical state:solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- No. of animals per sex per dose:
- 5 males and females
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 575.76 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Effects not observed.
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and "b" ) and ("c" and "d" ) )
Domain logical expression index: "a"
Similarity boundary:Target: C(=O)(O)CCCCCCCCCCCCCCCCCCC
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Low (Class I) by Toxic hazard classification by Cramer (original)
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is >= 7
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is <= 10.1
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The lethal dose (LD50) of Eicosanoic acid in New Zealand White rabbit was found to be 3575.76 mg/kg of body weight.Toxic effects was not observed. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Eicosanoic acid does not exhibit acute toxicity via the dermal route i.e it is acutely non toxic to animals within the dose level mentioned in the study.
- Executive summary:
The acute toxicity study was conducted to evaluate the toxic effects of administration of Eicosanoic acid to New Zealand White rabbit by the dermal route. The lethal dose (LD50) of Eicosanoic acid in rabbit was found to be 3575.76 mg/kg of body weight.Toxic effects was not observed. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Eicosanoic acid does not exhibit acute toxicity via the dermal route i.e it is acutely non toxic to animals within the dose level mentioned in the study.
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