Registration Dossier
Registration Dossier
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EC number: 208-031-3 | CAS number: 506-30-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Bio-anticlastogenic effects of unsaturated fatty acids included in fish oil - docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid - in cultured Chinese hamster cells
- Author:
- Sasaki, Yu. F.; Sakaguchi, Masaayuki; Yamagishi, Tatsunori; Yamada, Hiroshi; Shirasu, Yasuhiko
- Year:
- 1 994
- Bibliographic source:
- Mutation Research; vol. 320; nb. 1/2; (1994); p. 9 - 22
Materials and methods
- Principles of method if other than guideline:
- Data is from Mutation Research
- GLP compliance:
- not specified
- Type of assay:
- in vitro mammalian chromosome aberration test
Test material
- Reference substance name:
- Icosanoic acid
- EC Number:
- 208-031-3
- EC Name:
- Icosanoic acid
- Cas Number:
- 506-30-9
- Molecular formula:
- C20H40O2
- IUPAC Name:
- icosanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Eicosanoic acid
- Molecular formula: C20H40O2
- Molecular weight: 312.53
- Substance type:organic
- Physical state:solid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- Chinese hamster Ovary (CHO)
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- not specified
- Metabolic activation system:
- no data
- Test concentrations with justification for top dose:
- 5 - 20 mg/l
Results and discussion
Test results
- Species / strain:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Based on the data for in vitro mammalian chromosome aberration test on Chinese hamster Ovary (CHO K1) cells it was found that Eicosanoic acid does not exhibit positive chromosomal and cytotoxic effect . - Executive summary:
Based on the data for in vitro mammalian chromosome aberration test on Chinese hamster Ovary (CHO K1) cells it was found that Eicosanoic acid does not exhibit positive chromosomal and cytotoxic effect .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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