Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 691-719-4 | CAS number: 1072957-71-1
Neurotoxicity
Administrative data
Description of key information
acute and sub-chronic neurotoxicity studies (rat, oral exposure): no indication for neurotoxicity
Key value for chemical safety assessment
Additional information
The acute and sub-chronic neurotoxicity of the substance has been evaluated in the rat. There was no indication that the substance was neurotoxic. In the acute study, single gavage doses of 0, 10, 30 and 80 mg/kg/day did not produce any functional or pathological indications of neurotoxicity, although signs of general toxicity were observed at 30 mg/kg and above. In the sub-chronic neurotoxicity study, 90 days dietary administration at 0, 100, 250 and 800 ppm (males)/500 ppm (females) did not result in any indications of functional or pathological neurotoxicity. The NOAEL for generalized systemic toxicity was 100 ppm for males and 250 ppm for females, corresponding to 6.31 and 19.17 mg/kg/day respectively.
Remark of the registrant: The endpoint study record of the acute neurotoxicity study is missing in this dossier. It will be added in a subsequent update.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
