Registration Dossier

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

According to REACH Regulation (Annex IX, 9.3.2, column II), testing for bioaccumulation in aquatic species doesn't need to be conducted as the substance under investigation has a low potential to cross biological membranes and direct and indirect exposure of the aquatic compartment is unlikely.

Key value for chemical safety assessment

Additional information

No study for aquatic bioaccumulation with Bis(2-ethylhexyl) carbonate is available.

In a study conducted according to OECD Guideline 428, the penetration profile of the test substance Bis(2-ethylhexyl) carbonate (99.9 % a.i.) in human abdominal skin was analysed using an flow-through diffusion cell. The results of the in-study validation data show that the used method is able to quantify Bis(2-ethylhexyl) carbonate in cell culture medium with the respective precision and accuracy down to a concentration of 10.0 µg/mL for Bis(2-ethylhexyl) carbonate, corresponding to a detection limit of 0.025%. No Bis(2-ethylhexyl) carbonate could be detected in the skin penetration samples up to a skin exposition time of 24 h. Therefore, Bis(2-ethylhexyl) carbonate is not expected to penetrate the human skin. Comparable results are likely for animal organism.

It can be assumed that the test substance has a low potential to cross biological membranes.

Moreover, biotic degradation of the readily biodegradable substance in water leads to relatively low concentrations in the aquatic environment. Taking also into account the calculated high Henry's Law constant (criteria for the vapor pressure of the solution in water) Bis(2-ethylhexyl) carbonate is rapidly removed from the aquatic environment and direct and indirect exposure of the aquatic compartment is low.

Summarising, Bis(2-ethylhexyl) carbonate has a low potential to cross biological membranes and direct and indirect exposure of the aquatic compartment is unlikely.

Categories Display