Registration Dossier
Registration Dossier
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EC number: 202-257-6 | CAS number: 93-55-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Range - Finding Toxicity Data: List VIII.
- Author:
- Carpenter C.P., Weil C.S. and Smyth H.F.
- Year:
- 1 974
- Bibliographic source:
- Toxicology and Applied Pharmacology 28: 313-319
- Reference Type:
- other: mentioned publication descibing testing method and procedure
- Title:
- Range-finding toxicity data: List. VI.
- Author:
- Smyth H.F., Carpenter C.P., Weil C.S., Pozzani U.C. and Striegel J.A.
- Year:
- 1 962
- Bibliographic source:
- Amer. Ind. Hyg. Ass. J. 23, 95-107.
Materials and methods
- Principles of method if other than guideline:
- The experimental method followed the procedure described in earler paper (Smyth et al. 1962).
- GLP compliance:
- no
- Remarks:
- pre GLP
Test material
- Reference substance name:
- Propiophenone
- IUPAC Name:
- Propiophenone
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Type of coverage:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 490 other: mg/kg
- Based on:
- not specified
- Remarks on result:
- other: 2110-9540 mg/kg
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- according to the CLP Regulation (EC 1272/2008)
- Conclusions:
- LD50 rabbit: 4490 mg/kg
- Executive summary:
The experimental method followed the procedure described in earler paper (Smyth et al. 1962). No further details are available. Single oral LD50 for rats has been reported to be 4490 (2110 -9540) mg/kg.
Conclusion
LD50 rabbit: 4490 mg/kg
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