3-Furancarboxaldehyde, tetrahydro-

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1997-11-11 until 1997-11-25

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Scientifically valid study according to GLP and current OECD guideline.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Report date:

1998

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Version / remarks:

, adopted 1987

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.3 (Acute Toxicity (Dermal))

Version / remarks:

, adopted 1992

Deviations:

no

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

oxolane-3-carbaldehyde

EC Number:

629-664-5

Cas Number:

79710-86-4

Molecular formula:

C5 H8 O2

IUPAC Name:

oxolane-3-carbaldehyde

Test material form:

other: liquid

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Ltd, Hollister, CA
- Age at study initiation: 8 - 11 weeks
- Weight at study initiation: males: 273 - 297 g; femals: 224-252 g
- Housing: singly, suspended, stainless-steel, wire mesh cages
- Diet: Certified Rodent Diet (Purina Roden Chow #5002, pellets, ad libitum
- Water: drinking water, ad libitum, regulary analysed
- Acclimation period: 5 days

ENVIRONMENTAL CONDITIONS
- Temperature: 20-22°C
- Humidity: 49-50 %
- Photoperiod: 12 hours of artificial light

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: dorsal skin region
- % coverage: not less than 10 %
- Type of wrap if used: fiber pad and an occlusive wrap.

REMOVAL OF TEST SUBSTANCE
- Washing: using running water
- Time after start of exposure: 24 hours

TEST MATERIAL AND VEHICLE
The test substance was administered at a dose level of 2000 mg/kg bw

Duration of exposure:

24 hours

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

10 animals: 5 males, 5 females

Control animals:

not required

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: systemically between days 0-14, body weights were recorded on day 0, 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No adverse effects noted

Mortality:

No mortality was observed.

Clinical signs:

other: There were no signs of systemic reaction to treatment. There were no signs of systemic toxicity.

Gross pathology:

No abnormalities were noted.

Other findings:

none