Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

Currently viewing:

Administrative data

Endpoint:
in vitro DNA damage and/or repair study
Remarks:
Type of genotoxicity: DNA damage and/or repair
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Genotoxicity of amebicide and anthelmintic drugs in Escherichia coli pol A+/pol A−
Author:
J.J. Espinosa-Aguirre , C. Aroumir, M.T. Meza, E. Cienfuegos, C. Cortinas de Nava
Year:
1987
Bibliographic source:
Mutation Research/Genetic Toxicology Volume 188, Issue 2, June 1987, Pages 111-120

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: not available
GLP compliance:
not specified
Type of assay:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Diiodohydroxyquinoline
EC Number:
201-497-9
EC Name:
Diiodohydroxyquinoline
Cas Number:
83-73-8
Molecular formula:
C9H5I2NO
IUPAC Name:
5,7-diiodoquinolin-8-ol

Method

Species / strain
Species / strain / cell type:
E. coli, other: pol A+/pol A−
Additional strain / cell type characteristics:
not specified
Metabolic activation:
without
Metabolic activation system:
none
Test concentrations with justification for top dose:
DOSE : 260 nmol/plate
Vehicle / solvent:
no data
Controls
Untreated negative controls:
not specified
Negative solvent / vehicle controls:
not specified
True negative controls:
not specified
Positive controls:
not specified
Positive control substance:
not specified

Results and discussion

Test results
Species / strain:
E. coli, other: pol A+/pol A−
Metabolic activation:
not specified
Genotoxicity:
not specified
Cytotoxicity / choice of top concentrations:
not determined
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
other: not specified

DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 260 nmol/plate