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EC number: 276-594-2 | CAS number: 72361-35-4
Toxicological information
Skin irritation / corrosion
Currently viewing:
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Study period:
- 25 Feb - 11 Mar 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP - Guideline study. According to the ECHA guidance document "Practical guide 6: How to report read-across and categories (March 2010)", the reliability was changed from RL1 to RL2 to reflect the fact that this study was conducted on a read-across substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- (adopted in May 1981)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters
- EC Number:
- 304-780-6
- EC Name:
- 1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters
- Molecular formula:
- C36H60O6 to C42H72O6
- IUPAC Name:
- 1,2,4-Benzenetricarboxylic acid, tri-C9-11-alkyl esters, branched and linear
- Details on test material:
- - Name of test material (as cited in study report): only trade name given
- Date received: 12 Feb 1987
- Physical state: liquid
- Storage conditions: room temperature in the dark
- Analytical purity: 84%
- Specific Gravity: 0.9 g/cm
- Stability under test conditions: stable
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: The Broekman Institute, Someren, NL
- Age at study initiation: approximately 10 weeks
- Weight at study initiation: 2.574 - 2.901 kg
- Housing: individually in metal cages with perflorated floors
- Diet: 100 g/day, (LK-01, pellet diameter 4 mm, Hope Farms, Woerden)
- Water: tap water, ad libitum
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-21
- Humidity (%): 50-70
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: shame exposed site at the left flank of the same animal served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): unchanged liquid test substance
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
Reading time points: 55 min, 24, 48 and 72 h and 7 and 14 days - Number of animals:
- 3 females
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm² on the right flank
- Type of wrap if used: gauze patch mounted on permeable tape (Micropore, 3M, St. Paul, USA) and wrapped in flexible bandage (Coban, 3M, St. Paul, USA)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Residual test material was removed with dry tissue and subsequently a tissue moistened with tap water.
- Time after start of exposure: 4 h
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: mean over 24, 48 and 72 hours
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: mean over 24, 48 and 72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: mean over 24, 48 and 72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: mean over 24, 48 and 72 hours
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- The skin of all three animals showed well-defined erythema and very slight to slight edema. The redness had decreased to very slight within 24 h in animals #2 and #3 and on day 3 in animal #1. The irritation was reversible within 7 days in two animals and within 14 days in one animal.
- Other effects:
- Signs of systemic intoxication were not observed in any of the rabbits throughout the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
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