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EC number: 201-321-0 | CAS number: 81-07-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The lethal concentration (LC50) value of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in fish [Pimephales promelas] in a 96 hr study on mortality effect was found to be 18300 mg/L . Thus,considering the CLP Criteria for aquatic classification of the substance , it is concluded that 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibit short term toxicity to fish [Pimephales promelas].
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 18 300 mg/L
Additional information
Short term toxicity to fish:
No. of studies reviewed for Short-term toxicity to fish from reliable sources having Klimisch rating 2.
The summary of the results are presented below:
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
CAS No. |
Sources |
1 |
LC50 |
18300 mg/L |
Mortality |
96 hrs. |
Pimephales promelas |
81-07-2 |
Experimental data from Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales Promelas) |
2 |
NOEC |
2500 mg/L |
Behaviour |
24 - 26 hours post fertilization |
Danio rerio |
81-07-2 |
Experimental data from publication |
3 |
LC50 |
7272.4 mg/L |
Development |
24 to 72 hour(s) |
Danio rerio |
81-07-2 |
Experimental data from publication |
4 |
LC50 |
293.411 mg/L |
Mortality |
96 hrs. |
Leuciscus idus |
81-07-2 |
Predicted data from QSAR |
5 |
LC50 |
5585.3 mg/L |
Development |
144 hrs.(6 days) |
Danio rerio |
81-07-2 |
Experimental data from publication |
6 |
EC50 |
4755.5mg/L |
Development |
144 hrs.(6 days) |
Danio rerio |
81-07-2 |
Experimental data from publication |
7 |
LC50 |
>100 mg/L |
Mortality |
24-96 hrs. |
Poecilia reticulata |
Read across 128-44-9 |
Experimental data |
By applying weight of evidence approach to the target substance 1,2-benzisothiazol-3(2H)-one 1,1-dioxide and the read across substance 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt (which have more than 87.8% structural similarity),the endpoint value was found to vary between LC50 = >100 mg/L to 18300 mg/L in a 24 hrs.study to 96 hrs.study on the basis of mortality effect,EC50=4755.5mg/L basis of Development effect and NOEC for24 - 26 hours post fertilization period was reported as 2500 mg/L
Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that the test substance 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibits short term toxicity to fish (Leuciscus idus, Danio rerio ,Pimephales promelas and Poecilia reticulata).
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