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Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

The lethal concentration (LC50) value of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in fish [Pimephales promelas] in a 96 hr study on mortality effect was found to be 18300 mg/L . Thus,considering the CLP Criteria for aquatic classification of the substance , it is concluded that 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibit short term toxicity to fish [Pimephales promelas].

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
18 300 mg/L

Additional information

Short term toxicity to fish:

No. of studies reviewed for Short-term toxicity to fish from reliable sources having Klimisch rating 2.

The summary of the results are presented below:

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

CAS No.

Sources

1

LC50

18300 mg/L

Mortality

96 hrs.

Pimephales promelas

81-07-2

 Experimental data from Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales Promelas)

2

NOEC

2500 mg/L

Behaviour

24 - 26 hours post fertilization

Danio rerio

81-07-2

 Experimental data from publication

3

LC50

7272.4 mg/L

Development

24 to 72 hour(s)

Danio rerio

81-07-2

 Experimental data from publication

4

LC50

293.411 mg/L

Mortality

96 hrs.

Leuciscus idus

81-07-2

 Predicted data from QSAR

5

LC50

5585.3 mg/L

Development

144 hrs.(6 days)

Danio rerio

81-07-2

 Experimental data from publication

6

EC50

4755.5mg/L

Development

144 hrs.(6 days)

Danio rerio

81-07-2

 Experimental data from publication

7

LC50

>100 mg/L

Mortality

24-96 hrs.

Poecilia reticulata

Read across 128-44-9

 Experimental data 

 

By applying weight of evidence approach to the target substance 1,2-benzisothiazol-3(2H)-one 1,1-dioxide and the read across substance 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt (which have more than 87.8% structural similarity),the endpoint value was found to vary between LC50 = >100 mg/L to 18300 mg/L in a 24 hrs.study to 96 hrs.study on the basis of mortality effect,EC50=4755.5mg/L basis of Development effect and NOEC for24 - 26 hours post fertilization period was reported as 2500 mg/L

Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that the test substance 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibits short term toxicity to fish (Leuciscus idus, Danio rerio ,Pimephales promelas and Poecilia reticulata).