Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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EC number: 201-321-0 | CAS number: 81-07-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- [R]: 4.69E3 mg/kg bw; Estimation for LD50 for CAS 81-07-2
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 013
- Bibliographic source:
- QSAR Toolbox version 3.1
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Hazards Substances Act (Revised Federal Register Sept 17 1964)
- Principles of method if other than guideline:
- Standard acute method
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1,2-benzisothiazol-3(2H)-one 1,1-dioxide
- EC Number:
- 201-321-0
- EC Name:
- 1,2-benzisothiazol-3(2H)-one 1,1-dioxide
- Cas Number:
- 81-07-2
- Molecular formula:
- C7H5NO3S
- IUPAC Name:
- 1,2-benzisothiazol-3(2H)-one 1,1-dioxide
- Details on test material:
- - Name of test material (as cited in study report): 1,2-benzisothiazol-3(2H)-one 1,1-dioxide
- Substance type: Organic
- Physical state: solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 694 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Lethal dose ; 50 percent kill
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 15 - Nitrogen N AND Group 16 - Oxygen O AND Group 16 - Sulfur S by Chemical elements
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= -0.845
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 4.6
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal median lethal dose (LD50) of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in rabbit was found to be 4694 mg/kg of body weight. Acute toxicity of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide to rabbit by dermal route indicates that 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibits acute toxicity by the dermal route within the doses mentioned in the study.
- Executive summary:
</font> The acute dermal median lethal dose (LD50) of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in rabbit was found to be 4694 mg/kg of body weight. Acute toxicity of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide to rabbit by dermal route indicates that 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibits acute toxicity by the dermal route within the doses mentioned in the study.
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