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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
biochemical or cellular interactions
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The publication is in accordance with generally accepted scientific principles

Data source

Reference
Reference Type:
publication
Title:
Inhibition of growth of Ehrlich ascites tumors in ICR/Ha Swiss mice by isocyanate
Author:
Moos GE, Maguire JA, Kitchlew TZ, Swyers WA, Volk PZ, Croft JR, Quigley MJ, Fries JR, Oser NA, Anderson LJ
Year:
1971
Bibliographic source:
Cancer Res. 31, 937-941.

Materials and methods

Type of method:
in vitro

Test material

Constituent 1
Chemical structure
Reference substance name:
m-tolyl isocyanate
EC Number:
210-676-0
EC Name:
m-tolyl isocyanate
Cas Number:
621-29-4
Molecular formula:
C8H7NO
IUPAC Name:
1-isocyanato-3-methylbenzene
Details on test material:
m-tolylisocyanate was received from Eastman Organic Chemicals Department (Rochester, N.Y.)

Test animals

Species:
mouse
Strain:
Swiss
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
peanut oil
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
7 injections
Frequency of treatment:
daily
Post exposure period:
1 day (animals were sacrificed on day 8)
Doses / concentrations
Remarks:
Doses / Concentrations:
20 mg/kg bw/d
Basis:
nominal conc.
No. of animals per sex per dose:
test: 10 animals
control: 20 animals
Control animals:
yes, concurrent vehicle

Results and discussion

Any other information on results incl. tables

i.p. injections of 20 mg/kg/day over 7 days inhibition of growth of Ehrlich ascites tumors in ICR/Ha Swiss mice and
lengthening of the mean survival times of mice with Ehrlich ascites tumors

Applicant's summary and conclusion