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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well documented and scientifically acceptable

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Five male and 5 female young adult male Wistar rats (160 -180 g) per group reveived per gavage a single dose of 1000, 1500, 2000, 2500, 3100, 4000 or 5000 µl/kg bw m-tolylisocyanate. The animals were observed for mortality body weights and clinical signs through day 14.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
m-tolyl isocyanate
EC Number:
210-676-0
EC Name:
m-tolyl isocyanate
Cas Number:
621-29-4
Molecular formula:
C8H7NO
IUPAC Name:
1-isocyanato-3-methylbenzene

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
1000, 1500, 2000, 2500, 3100, 4000 or 5000 µl/kg bw (= ca. 1060, 1590, 2120, 2650, 3286, 4240, 5300 mg/kg bw)
No. of animals per sex per dose:
5 male and 5 female rats/group
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 926 mg/kg bw
Based on:
test mat.
95% CL:
2 380 - 3 210

Any other information on results incl. tables

The corresponding mortality for male rats was 0% (1000 µl/kg bw), 0% (1500 µg/kg bw), 20% (2000 µl/kg bw), 40% (2500 µg/kg bw), 40 (3100 µl/kg bw), 100% (4000 µl/kg bw) and 100% (5000 µl/kg bw) respectively.

The corresponding mortality for female rats was 0% (1000 µl/kg bw), 20% (1500 µg/kg bw), 20% (2000 µl/kg bw), 20% (2500 µg/kg bw), 60 (3100 µl/kg bw), 80% (4000 µl/kg bw) and 100% (5000 µl/kg bw) respectively.

Signs of intoxication: Sedation, reduction of gerneral condition. Fermale rats showed a body weight reduction at 1500 µl/kg bw and above. A dose of 1000 µl/kg bw was tolerated by male and female rats without symptoms.

The acute oral LD50 for male rats is 2760 µl/kg bw (= ca. 2926 mg/kg bw).

Applicant's summary and conclusion

Interpretation of results:
moderately toxic
Remarks:
Migrated information
Executive summary:

Five male and 5 female young adult male Wistar rats (160 -180 g) per group were dosed undiluted at 1000, 1500, 2000, 2500, 3100, 4000 or 5000 µl/kg bw m-tolylisocyanate. The animals were observed for mortality body weights and clinical signs through day 14.

Signs of intoxication: Sedation, reduction of gerneral condition. Fermale rats showed a body weight reduction at 1500 µl/kg bw and above. A dose of 1000 µl/kg bw was tolerated by male and female rats without symptoms.

The acute oral LD50 for male rats is 2760 µl/kg bw (= ca. 2926 mg/kg bw).