Registration Dossier

Diss Factsheets

Administrative data

Description of key information

skin irritation: in 2 valid studies m-tolylisocynante was corrosive to the skin 
eye irritation: in 2 valid studies m-tolylisocyanate was highly irritant to the eye

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

In 2 valid studies m-tolyl isocyanate was found corrosive to the skin.

In 2 valid studies on eye irritation, m-tolyl isocyanate was found highly irritating.


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: highly irritating

Justification for classification or non-classification

Due to the results of the key study for skin irritation/corrosion R34 is justified

Due to the severe effects on the eye R41 is justified

In addition, several studies reported respiration irritational effects. Therefore R 37 is applicable