Registration Dossier
Registration Dossier
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EC number: 201-055-5 | CAS number: 77-75-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Read across: 2 -Methylbut-3 -yn-2 -ol (CAS 115 -19 -5)
To assess the sensitising potential of 2 -Methylbut-3 -yn-2 -ol to skin, a Modified Split Adjuvant Test was taken into account (Rao, 1981). In this test, ten male Hartley Guinea pigs received four applications as induction to the clipped and depilated back of the animals. At the time of the third application, 0.2 ml of Freund's Adjuvant was injected intradermal at one point adjacent to the insult site. After a two week rest period, the animals received an application of pure 2-methylbut-3-yn-2-ol and reactions were evaluated 24 and 48 hours thereafter. As result, no sensitizing reactions could be observed.
Migrated from Short description of key information:
Read across to 2-Methylbut-3-yn-2-ol (CAS 115-19-5): not sensitizing (Modified Split Adjuvans Test, guinea pig)
Justification for classification or non-classification
Due to the negative results in a study with 2-Methylbut-3-yn-2-ol (read across) using a Modified Split Adjuvant Test, no classification for skin sensitization is required.
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