Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Study period:
11 March 2011
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable method for pigments with low solubilities

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Principles of method if other than guideline:
Calculation of log Pow from the solubility in water-saturated octanol (see section 4.9) and the solubility in octanol-saturated water (see section 4.8, study report number 0675Ce).
Type of method:
other: calculation
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
N-(4-chloro-2,5-dimethoxyphenyl)-2-[[2,5-dimethoxy-4-[(phenylamino)sulphonyl]phenyl]azo]-3-oxobutyramide
EC Number:
235-427-3
EC Name:
N-(4-chloro-2,5-dimethoxyphenyl)-2-[[2,5-dimethoxy-4-[(phenylamino)sulphonyl]phenyl]azo]-3-oxobutyramide
Cas Number:
12225-18-2
Molecular formula:
C26H27ClN4O8S
IUPAC Name:
N-(4-chloro-2,5-dimethoxyphenyl)-2-[[2,5-dimethoxy-4-[(phenylamino)sulphonyl]phenyl]azo]-3-oxobutyramide

Study design

Analytical method:
other: The analytical methods for the underlying data are given in section 4.8 and 4.9

Results and discussion

Partition coefficientopen allclose all
Type:
Pow
Partition coefficient:
18.9
Temp.:
26 °C
pH:
ca. 7
Type:
log Pow
Partition coefficient:
1.3
Temp.:
26 °C
pH:
ca. 7
Details on results:
See below

Any other information on results incl. tables

At ambient temperature (25 -26°C, 26°C given here), the solubility in octanol was determined to be 121 µg/L (section 4.9) and the solubility in water was determined to be 6.4 µg/L (section 4.8, study report number 0675Ce).

With the equation given above, the follwoing values were calculated:

Pow = 121 µg/L / 6.4 µg/L

Pow = 18.9

log Pow = 1.3

Applicant's summary and conclusion

Conclusions:
The test substance has a log Pow of 1.3.
Executive summary:

The log Pow of the test substance was calculated from the solubilities in octanol-saturated water and in water-saturated octanol. The log Pow at 26 °C was 1.3.