Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
biodegradation in soil
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
other: Prediction model
Title:
Biodegradation in soil by Environmental Science Center’s PBT profiler
Author:
Environmental Science Center
Year:
2010
Bibliographic source:
PBT profiler, Office of Chemical Safety and Pollution Prevention , U.S. Environmental Protection Agency; version 1.301
Reference Type:
other: Prediction model
Title:
Biodegradation in soil by EPI (Estimation Programs Interface) Suite
Author:
Sustainability Support Service (Europe) AB - estimated
Year:
2011
Bibliographic source:
Estimation Programs Interface Suite™ United States Environmental Protection Agency, Washington, DC, USA. version 4.1

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Modelling database
Principles of method if other than guideline:
PBT profiler database
Fugacity Model by EPI Suite estimation database
GLP compliance:
no
Test type:
other: estimated data

Test material

Constituent 1
Chemical structure
Reference substance name:
4-nitro-o-xylene
EC Number:
202-761-6
EC Name:
4-nitro-o-xylene
Cas Number:
99-51-4
Molecular formula:
C8H9NO2
IUPAC Name:
4-nitro-o-xylene
Details on test material:
Substance Name : 4-nitro-o-xylene
Molecular Formula : C8H9NO2
Physical state : Liquid
Radiolabelling:
not specified

Study design

Oxygen conditions:
other: estimated data
Soil classification:
not specified
Duration of test (contact time)
Soil No.:
#1
Duration:
75 d
Parameter followed for biodegradation estimation:
test mat. analysis

Results and discussion

% Degradation
Soil No.:
#1
% Degr.:
50
Parameter:
other: half-life
Sampling time:
75 d
Half-life / dissipation time of parent compound
Soil No.:
#1
DT50:
75 d
Type:
other: Estimated
Remarks on result:
other: 75 d = 1800 hr
Transformation products:
not specified
Evaporation of parent compound:
not specified
Volatile metabolites:
not specified
Residues:
not specified

Applicant's summary and conclusion

Conclusions:
The PBT Profiler & EPI Suite has estimated that 4-nitro-o-xylene is expected to be found predominantly in soil and its persistence estimate is based on its transformation in this medium. Its half-life in soil, 75 days., exceeds the EPA criteria .Therefore, 4-nitro-o-xylene is estimated to be persistent in the soil environment.
Executive summary:

The PBT Profiler & EPI Suite has estimated that 4-nitro-o-xylene is expected to be found predominantly in soil and its persistence estimate is based on its transformation in this medium. Its half-life in soil, 75 days., exceeds the EPA criteria .Therefore, 4-nitro-o-xylene is estimated to be persistent in the soil environment.

PBT Profiler Estimate

Media

Half-Life (days)

Percent in
Medium

Soil

75

   78%

Fugacity Model by EPI Suite estimation database

 

Mass Amount (percent)

Half-Life (hr)

Emissions (kg/hr)

Soil

80

1.8e+003

1000

 

Fugacity (atm)

Reaction (kg/hr)

Advection (kg/hr)

Reaction (percent)

Advection (percent)

Soil

3.09e-009

922

0

30.7

0

Persistence Time: 999 hr

Reaction Time: 1.91e+003 hr

Advection Time: 2.09e+003 hr

Percent Reacted: 52.3

Percent Advected: 47.7

 

Half-Lives (hr), (based upon Biowin (Ultimate) and Aopwin):

Air: 244.1

Water: 900

Soil: 1800

Sediment: 8100

Biowin estimate: 2.546 (weeks-months)

 

Advection Times (hr):

Air: 100

Water: 1000

Sediment: 5e+004