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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Authoritative databases
Title:
Revised Robust Study Summaries and Test Plan for 1,2-dimethyl-4-nitrobenzene
Author:
U.S. Environmental Protection Agency
Year:
2006
Bibliographic source:
High Production Volume (HPV) Challenge; Fisher, J., 1975, Toxicity data for o-xylene,4-nitro. Report No. A75-138, American Cyanamid Company, Agricultural Division, Princeton, NJ.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is taken from HPV challenge program.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-nitro-o-xylene
EC Number:
202-761-6
EC Name:
4-nitro-o-xylene
Cas Number:
99-51-4
Molecular formula:
C8H9NO2
IUPAC Name:
4-nitro-o-xylene
Details on test material:
Substance Name : 4-nitro-o-xylene
Molecular Formula : C8H9NO2
Physical state : Liquid

Test animals

Species:
rabbit

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 5 695 mg/kg bw
Clinical signs:
Details of toxic effects not reported other than lethal dose value

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Dermal toxicity test with rabbits indicates a LD50 greater than 5,695 mg/kg b.w.. Based on the results, 4-nitro-o-xylene is not likely to cause any acute toxic effects via dermal route of exposure.
Executive summary:

Dermal toxicity test with rabbits indicates a LD50 greater than 5,695 mg/kg b.w.. Based on the results, 4-nitro-o-xylene is not likely to cause any acute toxic effects via dermal route of exposure.