Registration Dossier
Registration Dossier
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EC number: 700-755-2 | CAS number: -
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
- Principles of method if other than guideline:
- Rats were administered a single intravenous injection to the tail vein to determine the tolerability of the test substance by the i.v. route.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- (2E)-1,1,1,2,3,4,5,5,6,6,7,7,7-tridecafluoro-4-methoxyhept-2-ene; (3E)-1,1,1,2,2,3,4,5,6,6,7,7,7-tridecafluoro-5-methoxyhept-3-ene; (3E)-1,1,1,2,2,4,5,5,6,6,7,7,7-tridecafluoro-3-methoxyhept-3-ene
- EC Number:
- 700-755-2
- Molecular formula:
- C8H3F13O
- IUPAC Name:
- (2E)-1,1,1,2,3,4,5,5,6,6,7,7,7-tridecafluoro-4-methoxyhept-2-ene; (3E)-1,1,1,2,2,3,4,5,6,6,7,7,7-tridecafluoro-5-methoxyhept-3-ene; (3E)-1,1,1,2,2,4,5,5,6,6,7,7,7-tridecafluoro-3-methoxyhept-3-ene
- Details on test material:
- - Purity: 99.3%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- other: ethanol/PEG 400 (20:80)
- Doses:
- 0, 1, 5 mg/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: NOEL
- Effect level:
- 5 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: highest dose tested; no adverse effects observed
Applicant's summary and conclusion
- Conclusions:
- No deaths, clinical signs, or body weight losses were oberved in rats at 1 or 5 mg/kg.
- Executive summary:
Rats were administered a single intravenous injection of the test substance at 1 or 5 mg/kg to the tail vein. Animals were observed for 4 days after test substance administration. No deaths, clinical signs, or body weight losses were observed at 1 or 5 mg/kg. Under the conditions of the study, the no adverse effect level (NOEL) was 5 mg/kg (the highest dose tested).
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