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Environmental fate & pathways

Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09 - 12 Jun 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC estimation method
Media:
soil/sewage sludge
Radiolabelling:
no
Test temperature:
25 °C
Details on study design: HPLC method:
EQUIPMENT
- Apparatus: HPLC autosampler and pump, Waters 2695
- Type, material and dimension of analytical (guard) column: Lichrospher 100 CN, 250/4 mm, 5 µm
- Detection system: PDA detector, Waters 996

MOBILE PHASES
- Type: 55% methanol / 45% aqueous buffer solution (0.01 M citric acid at pH 6.0) (v/v)
- Experiments with additives carried out on separate columns: no

DETERMINATION OF DEAD TIME
- Method: by means of homologous series / by inert substances which are not retained by the column

REFERENCE SUBSTANCES
- Identity: Sodium nitrate, acetanilide, phenol, methyl benzoate, naphthalene, 1,2,3-trichlorobenzene, phenanthrene, basic blue 41

DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 0.00223 - 0.00442 mg
- Quantity of reference substances: 0.0035 - 0.0050 mg

REPETITIONS
- Number of determinations: 3

EVALUATION
- Calculation of capacity factors k': = (tr-to) + to
Key result
Type:
log Koc
Value:
3.9
Temp.:
25 °C
Details on results (HPLC method):
- Retention times of reference substances used for calibration: sodium nitrate: 1.979, acetanilide: 3.226, phenol: 3.254, methyl benzoate: 3.759, naphthalene: 5.653, 1,2,3-trichlorobenzene: 5.619, phenanthrene: 9.042, basic blue 41: 13.196
- Details of fitted regression line (log k' vs. log Koc): y = 3.783x + 1.994 (with x = log k' and y = log Koc); R = 0.996
- Average retention data for test substance: 6.27, 7.27, 8.30
Validity criteria fulfilled:
yes
Conclusions:
In a study according to OECD test guideline 121 under GLP conditions, the adsorption coefficient log Koc of the registered substance is determined to be 3.9.
Executive summary:

The adsorption coefficient log Kocof the registered substance was performed according to OECD guideline 121. The log Koc value is determined to be 3.9.

Description of key information

Adsorption is expected based on a measured log Koc value of 3.9 (OECD 121)

Key value for chemical safety assessment

Koc at 20 °C:
7 943.3

Additional information

One study investigating the adsorption potential of Ethanone, 1-(2-hydroxy-5-nonylphenyl)-, oxime, branched (CAS 244235-47-0) is available. The study was performed according to GLP and OECD guideline 121 (Frischmann 2010). The log Koc value at 25 °C is determined to be 3.9 (Koc = 7943.3). This value indicate that the substance exhibit potential for adsorption to organic soil and sediment particles.

[LogKoc: 3.9]