Registration Dossier
Registration Dossier
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EC number: 606-376-8 | CAS number: 197721-70-3
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
GLP study according to EU testing method A.8 (HPLC Method).
General Physical Chemistry, Schering AG, Berlin. Study report No. NC33EY10 (APC 53/99), dated 1999-09-22
Result: log Pow = 1.7 (95% confidence limits 1.4 to 1.9) at pH 7, 25°C
Key value for chemical safety assessment
- at the temperature of:
- 20 °C
Additional information
The partition coefficient n- octanol / water was determined according to EU testing method A.8, following OECD guideline 117:
-HPLC conditions:
column: 150 x 4.6 mm, filled with Luna C18, 5µm
eluent: methanol/buffer pH7, 75 +25 (v+v)
flow rate: 1.0 mL/min
temperature: 25°C
detection: UV
-dead time determination: from retention times of a homologous series of compounds (n-alkyl ketones)
- log Pow calibration: regression line log k' versus lod Pow of reference substances (log Pow range 0.3 to 4.9)
Result: log Pow = 1.7 (95% confidence limits 1.4 to 1.9)
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