Registration Dossier
Registration Dossier
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EC number: 700-292-6 | CAS number: 135043-68-4
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Follows a recognised guideline and conforms to GLP standards.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- trisodium 6,6',6"-(1,3,5-triazine-2,4,6-triyltriimino)trihexanoate
- IUPAC Name:
- trisodium 6,6',6"-(1,3,5-triazine-2,4,6-triyltriimino)trihexanoate
Constituent 1
Results and discussion
Particle size
- Percentile:
- D50
- Mean:
- > 100 µm
- Remarks on result:
- other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- 44.4 %
- No.:
- #2
- Size:
- < 10 µm
- Distribution:
- <= 0.638 %
- No.:
- #3
- Size:
- < 5.5 µm
- Distribution:
- <= 0.296 %
Any other information on results incl. tables
Screening test results
| Sieve aperture size (micrometres) | 100 |
| Mass of test material transferred to sieve (g) | 11.35 |
| Mass of test material passed through sieve (g) | 5.04 |
| Test material less than sieve size (%) | 44.4 |
Definitive test results:
Overall cumulative amounts of trisodium 6,6',6"-(1,3,5-triazine-2,4,6-triyltriimino)trihexanoate with a particle size less than 10.0 micrometres (%) from determinations 1 - 3:
| Determination | Cumulative amount of test material less than 10.0 micrometres (%) | Overall cumulative amount of test material less than 10.0 micrometres (%) |
| 1 | 0.383 | </= 0.638 |
| 2 | 0.601 | |
| 3 | 0.638 |
Overall cumulative amounts of test material with a particle size less than 5.5 micrometres (%) from determinations 1 - 3:
| Determination | Cumulative amount of test material less than 10.0 micrometres (%) | Overall cumulative amount of test material less than 10.0 micrometres (%) |
| 1 | 8.06E-02 | = 0.296 |
| 2 | 0.262 | |
| 3 | 0.296 |
Applicant's summary and conclusion
- Conclusions:
- Particle size data acquired for trisodium 6,6',6"-(1,3,5-triazine-2,4,6-triyltriimino)trihexanoate is as follows:
Proportion of trisodium 6,6',6"-(1,3,5-triazine-2,4,6-triyltriimino)trihexanoate having an inhalable particle size less than 100 μm (sieve method): 44.4%.
Proportion of test material having a thoracic particle size less than 10.0 μm (Cascader impactor method): Proportion of test material having a respirable particle size less than 5.5 μm (Cascader impactor method):
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