Registration Dossier
Registration Dossier
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EC number: 276-171-2 | CAS number: 71902-01-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (3h) = 14.4 mg/L OECD 301 B, toxicity control, activated sludge)
Key value for chemical safety assessment
Additional information
The toxicity of Sorbitan isooctadecanoate (CAS No. 71902-01-7) to microorganisms was tested in a toxicity control during a ready biodegradation study (OECD 301 B). If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2012). A substance can be assumed to be not inhibitory to aquatic microorganisms, if in the toxicity control of a ready biodegradation test, more than 25% degradation based on CO2 evolution (CO2/ThCO2) occurred within 14 days (OECD guideline 301).
For Sorbitan isooctadecanoate a biodegradation test according to OECD guideline 301 B is available (Clarke, 2012). The test includes a toxicity control, which contains 14.4 mg/L of Sorbitan, octanoate (2:3) and 17.1 mg/L of the reference material sodium benzoate. The toxicity control attained 82% degradation after 14 days of incubation. Hence, the substance is not toxic to aquatic microorganisms in the toxicity control and the test item concentration of 14.4 mg/L can be used as NOEC.
Hence, Sorbitan isooctadecanoate is not expected to have effects on activated sludge microorganisms.
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