[No public or meaningful name is available]

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

1971-06-28 to 1971-08-16

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: equivalent to guideline study; no GLP study, but acceptable, well-documented study report

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

the study was performed prior to the adoption of the OECD Guideline

Deviations:

yes

Remarks:

, see "Principles of method if other than guideline"

Principles of method if other than guideline:

One concentration level for a one-hour period was tested.

GLP compliance:

no

Test type:

other: Acute Inhalation Toxicity

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Diallyl 2,2'-oxydiethyl dicarbonate

EC Number:

205-528-7

EC Name:

Diallyl 2,2'-oxydiethyl dicarbonate

Cas Number:

142-22-3

Molecular formula:

C12H18O7

IUPAC Name:

diallyl 2,2'-oxydiethyl dicarbonate

Details on test material:

- Name of test material (as cited in study report): CR-39, 62310-31-151- 1006
- Substance type: organic
- Physical state: clear colorless liquid
- Analytical purity: data not available
- Impurities (identity and concentrations): data not available
- Composition of test material, percentage of components (from a conversation letter of PPG Industries Inc. and the test facility, dated 1971-06-08):
- total chlorine 0.02 %,
- chloroformate chlorine <0.001% ,
- volatile material 0.21%
- Isomers composition: data not available
- Purity test date: data not available
- Lot/batch No.: 62310-31-151- 1006
- Expiration date of the lot/batch: data not available
- Stability under test conditions: data not available
- Storage condition of test material: data not available

Test animals

Species:

rat

Strain:

other: Albino

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Breeding Laboratories, Inc.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

1 h

Concentrations:

The average nominal vapor concentration, calculated by dividing the generator weight loss by the total volume of air used during the test, was 0. 73 mg/L air at 29. 92 inches Hg and 25 °C

No. of animals per sex per dose:

5 males/5 females

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

other: average nominal vapor concentration

Effect level:

0.73 mg/L air (nominal)

Exp. duration:

1 h

Any other information on results incl. tables

No deaths or untoward behavioral reactions were noted during the exposure period. The 14-day observation period was uneventful.

The average 14-day body weight gain was 48 grams which is within normal limits.

Necropsy did not reveal any gross pathologic alterations which could be attributed to inhalation of test material vapors.

Applicant's summary and conclusion

Interpretation of results:

other: Single exposure level tested might be unsufficient to interpret the results

Remarks:

Criteria used for interpretation of results: not specified

Conclusions:

No toxic effects of test material could be determined in test animals after the single level acute inhalation

Executive summary:

Since the multi-constituent to be registered (EC 700-483-4) contains as main ingredient 'diallyl 2,2'oxydiethyl dicarbonate', the experimental data from this substance were used in a read-across approach.

An acute inhalation toxicity study was conducted (prior to the adoption of the OECD Guideline) wherein a group of ten albino rats was exposed to the vapors of CR-39 for a one-hour period at an average nominal concentration of 0.73 mg/L air. After exposure, the test animals were observed for the following 14 days.

No deaths, untoward behavioral reactions or gross pathologic alterations were noted in any of the test animals. Body weight gains were within the normal limits.