Registration Dossier
Registration Dossier
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EC number: 941-303-6 | CAS number: 1689576-55-3
Endpoint summary
Administrative data
Description of key information
- Acute toxicity:
Oral: LD50: >2000 mg/kg in the rat
Inhalation (4 hours) LD50: > 2600 mg / m3 in the rat
Dermal: LD50: > 2000 mg/kg in the rabbit
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- A number of studies are available on three structural analogues of the registered substance, all demonstrating the LD50 to be in excess of 2000 mg/kg body weight.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 2 600 mg/m³ air
- Quality of whole database:
- A single reliable study is available on a structural analogue of the registered substance, this demonstrating the LD50 to be in excess of the maximum concentration technically possible to achieve in the atmosphere..
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Studies are available on two structural analogues of the registered substance, all demonstrating the LD50 to be in excess of 2000 mg/kg body weight.
Additional information
Data are available from a number of studies on up to three structural analogues of the registered substance. A number of these are older studies and the details available are not adequate to permit robust evaluation of the reported findings.
It is noted that, when assessing acute toxicity by the inhalation route, the limit concentrations for gases, vapours, and aerosols are 20000 ppm, 20 mg/L, and 5 mg/L, respectively (or the maximum attainable concentration). It is recognized that it is technically challenging to generate limit concentrations as aerosols and, with most substances, a concentration of 2 mg/L (2000 mg/m3) is the approximate limit at which a respirable particle size can be achieved.
Justification for classification or non-classification
Classification with regard to acute oral and dermal toxicity is not justified based on the observed lack of mortality at a dose level of 2000 mg/kg.
Classification with regard to acute (4 hour) inhalation toxicity is not justified based on the observed lack of mortality at an exposure level of 2600 mg / m3, regarded as being the highest achievable exposure concentration.
Classification according to the criteria of Regulation 1272/2008/EC (CLP) and Directive 67/548/EEC (DSD) is therefore not indicated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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