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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
DPIM: TIJ150
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials):- Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al., Moscow, USSR.:  , Centre of International Projects, GKNT, 1982, 113.
Reference Type:
review article or handbook
Title:
RTECS No. AO 7140000
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):- Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure; Izmerov, N.F., et al., Moscow, USSR.:Centre of International Projects, GKNT, 1982, 113.
Reference Type:
review article or handbook
Title:
Dose doc no. : T230
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE):- Izmerov, N. F. et al Toxicometric Parameters of Industrial Toxic Chemicals under Single Exposure 1982, CIP, Moscow, USSR.
Reference Type:
other: Authoritative data base
Title:
ACToR Database: actor_2010q4a
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from SAX database
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloroacetyl chloride
EC Number:
200-926-7
EC Name:
Trichloroacetyl chloride
Cas Number:
76-02-8
Molecular formula:
C2Cl4O
IUPAC Name:
trichloroacetyl chloride

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
600 other: mg/kg
Remarks on result:
other: Details of toxic effects not reported other than lethal dose value

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 value of the substance is found to be 600 mg/kg in rat by oral route.
Executive summary:

The LD50 value of the substance is found to be 600 mg/kg in rat by oral route. This value indicates that trichloroacetyl chloride can be classified as "acute toxic category 4"

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