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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
DPIM: TIJ150
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials):- Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al., Moscow, USSR.:  , Centre of International Projects, GKNT, 1982, 113.
Reference Type:
review article or handbook
Title:
RTECS No. AO 7140000
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):- Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al., Moscow, USSR.:  , Centre of International Projects, GKNT, 1982, 113.
Reference Type:
review article or handbook
Title:
T230
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE):- Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al., Moscow, USSR.:  , Centre of International Projects, GKNT, 1982, 113.
Reference Type:
other: Authoritative data base
Title:
ACToR no : actor_2010q4a
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource); Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure, Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 113, 1982.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from SAX database
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloroacetyl chloride
EC Number:
200-926-7
EC Name:
Trichloroacetyl chloride
Cas Number:
76-02-8
Molecular formula:
C2Cl4O
IUPAC Name:
trichloroacetyl chloride

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation
Duration of exposure:
4 h

Results and discussion

Effect levels
Dose descriptor:
LC50
Effect level:
475 other: mg/m3
Based on:
test mat.
Exp. duration:
4 h

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 value of the substance is found to be 600 mg/kg in rat by inhalation.
Executive summary:

Trichloroacetyl chloride is not toxic by the inhalation route since the LD50 value of the substance is found to be 600 mg/kg in rat by inhalation

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