Zinc bis(dibutyldithiocarbamate)

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

effects on growth of green algae

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: read-across from a comparable to guideline and with acceptable restrictions study

Justification for type of information:

The long-term toxicity of zinc bis(dibutyldithiocarbamate) to aquatic invertebrates is based on read-across from the structural analogue zinc bis(diethyldithiocarbamate).

Reason / purpose for cross-reference:

read-across source

Key result

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

1.1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Reference 2

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

OECD guideline study, published in lierature, minor restrictions in reporting, but otherwise adequate for assessment

Qualifier:

according to guideline

Guideline:

OECD Guideline 201 (Alga, Growth Inhibition Test)

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Chlorella pyrenoidosa

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Test temperature:

20± 1 °C

Details on test conditions:

TEST SYSTEM
- Test vessel: Erlenmeyer flasks
- Type (delete if not applicable): closed
- Material, size, headspace, fill volume: 200 ml
- Aeration: placed on a mechanical shaker
- Initial cells density: approximately 10E8 cells .1E-1 (100 ml)
- The tests were carried out in triplicate.

TEST MEDIUM / WATER PARAMETERS
- The composition of the medium used is given elsewhere (Van Leeuwen and Maas, 1985).

OTHER TEST CONDITIONS
- Light intensity and quality: placed under fluorescent light (7.5 W/m²)

Reference substance (positive control):

not specified

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

1.1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Description of key information

The 96-h ErC50 of 1.1 mg/L in Chlorella pyrenoidosa will be used in the assessment.

Key value for chemical safety assessment

EC50 for freshwater algae:

1.1 mg/L

Additional information

No growth inhibition tests with algae are available for zinc bis(dibutyldithiocarbamate). The results from the structural analogue zinc diethyldithiocarbamate are used (for details see Reporting Format as attached to the respective IUCLID entry and CSR Appendix A.1). A 96-h ErC50 value of 1.1 mg/L in Chlorella pyrenoidosa from a semi-static non-GLP, OECD 201 guideline study without analytical monitoring (van Leeuwen et al., 1985b) is used in the assessment.