Registration Dossier

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
21 May 2008 and 02 June 2008.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
The work described was performed in compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)).
Type of method:
other: differential scanning calorimetry (DSC)

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Melting / freezing point
Melting / freezing pt.:
627 K
Atm. press.:
101.2 kPa
Decomposition:
yes
Decomp. temp.:
ca. 627 K
Sublimation:
no
Remarks on result:
other: initial screening tests indicated that the test material melted (with decomposition) close to the 360°C maximum test temperature indicated in the guideline.

Any other information on results incl. tables

Results

Thermographic data for Determinations 1 and 2 are shown in the following tables respectively.

Thermographic Data Determination 1

Thermal Event

Interpretation

Temperature

ºC

K

Endotherm

Melting (with decomposition) temperature

353.51

626.66

Atmospheric pressure: 101.2 kPa

Residue: light brown solid

Thermographic Data Determination 2

Thermal Event

Interpretation

Temperature

ºC

K

Endotherm

Melting (with decomposition) temperature

353.35

626.50

Atmospheric pressure: 101.2 kPa

Residue: light brown solid

Mean melting (with decomposition) temperature: 627 ± 0.5 K

Discussion

The temperature range of the test was extended to 400°C, as initial screening tests indicated that the test material melted (with decomposition) close to the 360°C maximum test temperature indicated in the guideline.

Similar thermographic profiles were obtained using air and nitrogen atmospheres; this indicates that the observed (melting with) decomposition is probably thermal and not oxidative.

Melting with decomposition was confirmed using a metal block test.

Conclusion

The test material has been determined to melt (with decomposition) at 627 ± 0.5 K.

Applicant's summary and conclusion

Conclusions:
The test material has been determined to melt (with decomposition) at 627 ± 0.5 K.
Executive summary:

The determination was carried out by (DSC) using the procedure specified in ASTM E537-86, Method A1 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC).

The test material has been determined to melt (with decomposition) at 627 ± 0.5 K.