2-Pentanone, 2,2',2''-[O,O',O''-(ethenylsilylidyne)trioxime]

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Read-across from an analogue substance for which a guideline study (KIimish = 1) is available.

Justification for type of information:

See reporting format for the analogue approach attached.

Reason / purpose for cross-reference:

read-across source

Nominal and measured concentrations:

 

Key result

Duration:

28 d

Dose descriptor:

NOEC

Effect conc.:

> 22.2 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

other: CO2evolution

Remarks on result:

other: Based on a read-across from an analogue for which EC50 > 21.5 mg/L

Conclusions:

Based on the read-across approach from the analogue substance OS1600, the NOEC (28 days) of OS2600 for microorganism toxicity was determined to be 22.2 mg/L.

Executive summary:

Microbial toxicity was derived from an available ready biodegradation test performed with the analogue substance OS1600 in accordance with OECD Guideline 301B. Since in the toxicity control more than 25% degradation occurred within 14 days (32 % based on ThCO2) it was considered that the test substance does not inhibit microbial activity. The NOEC (28d) of OS1600 was determined to be 21.5 mg/L. Based on these results, the read-across approach was applied and the NOEC (28d) of OS2600 for microorganism toxicity was determined to be 22.2 mg/L.

Description of key information

Based on the read-across approach from the analogue substance OS1600, the NOEC (28 days) of OS2600 for microorganism toxicity was determined to be 22.2 mg/L since the test item does not inhibit microbial activity.

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:

22.2 mg/L

Additional information

Key study: Read-across approach from experimental data on the analogue substance OS1600: Microbial toxicity was derived from an available ready biodegradation test performed with the analogue substance in accordance with OECD Guideline 301B (GLP study). Based on the read-across approach from the analogue substance OS1600 (NOEC = 21.5 mg/L), the NOEC for OS2600 was determined to be 22.2 mg/L for microorganism toxicity.