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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
other: OECD 105
Deviations:
no
GLP compliance:
no
Medium:
n-octanol
Solubility:
0.4 g/L
Temp.:
20 °C
Test substance stable:
yes

Preliminary test:

mL of n-octanol for 0,1 g soluble

0,1

0,5

1

2

10

100

150

approx. solubility in g/L

>1000

1000 to 200

200 to 100

100 to 50

50 to 10

10 to 1

<1

visual evaluation

not soluble

not soluble

not soluble

not soluble

not
soluble

not
soluble

not
soluble

 

Solubility test: 

Flask No.

Equilibration time at 20 °C
[h]

Active content
[g/L]

1

24

0,41

2

48

0,40

3

72

0,39

mean

---

0,40

 

 

Conclusions:
Solubility in n-octanol: 0.40 g/L at 20°C
Executive summary:

The solubility of the test item in n-octanol was determined according to the flask method as described in the OECD Guideline for the Testing of Chemicals 105, adapted to this solvent.

Result: Solubility in n-octanol (20 °C): 0,40 g/L

Description of key information

Solubility in n-octanol: 0.40 g/L at 20°C (OECD 105, flask method)

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
0.4 g/L

Additional information

The solubility of the test item in n-octanol was determined according to the flask method as described in the OECD Guideline for the Testing of Chemicals 105, adapted to this solvent.