Registration Dossier
Registration Dossier
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EC number: 257-288-8 | CAS number: 51566-62-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP compliant, non guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A dermal LD50 study was determined in 10 rabbits, exposed to 5000 mg/kg of the test material.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,7-dimethyloct-6-enenitrile
- EC Number:
- 257-288-8
- EC Name:
- 3,7-dimethyloct-6-enenitrile
- Cas Number:
- 51566-62-2
- Molecular formula:
- C10H17N
- IUPAC Name:
- 3,7-dimethyloct-6-enenitrile
- Details on test material:
- - Name of test material (as cited in study report): Citronellyl Nitrile ; 77-87 (no further data)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- A dermal LD50 study was conducted on 10 rabbits, using 5000 mg/kg of the test material. The animals were observed for 14 days for mortality and signs. A necropsy was conducted on both the animals that died and on the survivors after day 14. No further details were provided.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- 0/10 animals
- Clinical signs:
- other: Mild redness in 10/10 animals and mild to moderate edema in 9/10 animals. No furhter clinical signs observed.
- Gross pathology:
- Fecal matter anogenitally (2 animals), Kidneys: pocked (1 animal), mottled (2 animals), Spleen: Blue-grey sections (1 animal). In six animals no abnormalities were observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
