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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1979 - 1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented report which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not specified
Remarks:
; study performed prior to OECD TG 403
Principles of method if other than guideline:
Method: other: BASF-Test, see details in the section "Any other information on materials and methods incl. tables".
GLP compliance:
no
Remarks:
study was performed prior to GLP implementation
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2-dimethyloxirane
EC Number:
209-193-8
EC Name:
2,2-dimethyloxirane
Cas Number:
558-30-5
Molecular formula:
C4H8O
IUPAC Name:
2,2-dimethyloxirane
Details on test material:
Please refer to the section "confidential details on test material" below.

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: young adult (based on body weight)
- Weight at study initiation: 225 to 218 g (male), 185 - 198 g (female)
- Diet: H. EGGERSMANN KG, Germany

IN-LIFE DATES: From: 1979-03-19 To: 1979-04-03

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
Animals were exposed by inhalation to a saturated vapor-air mixture of the test substance at 20 degrees centigrade
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
>= 3 - <= 25 min
Concentrations:
3 min: ca. 133394 ppm (approximately 400 mg/L)
10 min: ca. 225072 ppm (approximately 674 mg/L)
25 min: ca. 279998 ppm (approximately 839 mg/L)
No. of animals per sex per dose:
6 animals (3 min), 3 animals (10, 25 min)
Control animals:
no
Details on study design:
Please refer to details in the section "Any other information on materials and methods incl. tables".

Results and discussion

Mortality:
After 3 min 1/12, after 10 and 25 min 4/6 rats died.
Clinical signs:
other: - escape attempts - eyelid closure - salivation - intermittent respiration - gasping - discharge (eyes, nose) - ruffy fur - slight erythema (ears, extremities) - unsteady gait
Gross pathology:
Animals died during the study: heart - right-sided acute dilatation, acute hyperaemia; lung - edema
Animals sacrificed: organs without findings

Any other information on results incl. tables

Since test results depending on toxicity and volatility, conclusions on the acute inhalation toxicity are not possible.

Applicant's summary and conclusion