Registration Dossier

Administrative data

Endpoint:
surface tension
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Testing was conducted between 16 May 2008 and 13 June 2008.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not effect the quality of the relevant results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.5 (Surface Tension)
Deviations:
yes
Principles of method if other than guideline:
The determination was carried out using a White Electrical Institute interfacial tension balance and a procedure based on the ISO 304 ring method. With the exception of the following deviation, the experimental procedure used complied with that specified in Method A5 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC).
1) The surface tension result was not corrected using the Harkins-Jordan correction table as the correction is not applicable to the apparatus used. Once calibrated, the balance and ring assembly used in this test give a direct reading for surface tension that is within the required accuracy (± 0.5 mN/m); this is as a result of the reduced ring dimensions.
This deviation has been considered not to have affected the integrity of the study.
GLP compliance:
yes (incl. QA statement)
Remarks:
The work described was performed in compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)).
Type of method:
ring method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Surface tension
Surface tension:
71.9 mN/m
Temp.:
21.4 °C
Conc.:
1 g/L

Any other information on results incl. tables

Results

    Calibration factor (f)

The readings, temperatures and the corresponding calibration factors for glass double-distilled water are shown in the following table:

Reading (mN/m)

Temperature (ºC)

Literature Value (mN/m)

Calibration Factor

72.5

21.4

72.50

1.000

72.5

21.4

72.50

1.000

72.5

21.4

72.50

1.000

72.5

21.4

72.50

1.000

72.5

21.4

72.50

1.000

72.5

21.4

72.50

1.000

Mean Calibration Factor = 1.000

Sample solution readings

The readings, times and temperatures for the sample solution are shown in the following table:

Time (mins)

Reading (mN/m)

Temperature (ºC)

106

71.5

21.4

113

72.0

21.4

121

72.0

21.4

131

72.0

21.4

144

72.0

21.4

Mean reading                     :    71.9 mN/m
Surface tension                   =  reading x calibration factor
                                          =  71.9 x 1.000
                                          =  71.9mN/m
Temperature                       :    21.4 ± 0.5ºC
pH of sample solution         :    6.7

         Discussion

Substances showing a surface tension lower than 60 mN/m should be regarded as being surface-active.

Conclusion

The surface tension of a 1.00 g/l solution of test material has been determined to be 71.9 mN/m at 21.4 ± 0.5°C.  The test material is considered not to be a surface-active material.

Applicant's summary and conclusion

Conclusions:
The surface tension of a 1.00 g/l solution of test material has been determined to be 71.9 mN/m at 21.4 ± 0.5°C. The test material is considered not to be a surface-active material.
Executive summary:

The surface tension of a 1.00 g/l solution of test material Na-Na in project number 1307 -0436 has been determined to be 71.9 mN/m at 21.4 ± 0.5°C. The test material is considered not to be a surface-active material.The determination was carried out using a White Electrical Institute interfacial tension balance and a procedure based on the ISO 304 ring method. With the exception of the following deviation, the experimental procedure used complied with that specified in Method A5 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC)

The surface tension result was not corrected using the Harkins-Jordan correction table as the correction is not applicable to the apparatus used.  Once calibrated, the balance and ring assembly used in this test give a direct reading for surface tension that is within the required accuracy (± 0.5 mN/m); this is as a result of the reduced ring dimensions.

This deviation has been considered not to have affected the integrity of the study.