N-(4-chloro-2,5-dimethoxyphenyl)-3-hydroxy-4-[(E)-2-[2-methoxy-5-(phenylcarbamoyl)phenyl]diazen-1-yl]naphthalene-2-carboxamide; N-(5-chloro-2-methylphenyl)-3-hydroxy-4-[(E)-2-[2-methoxy-5-(phenylcarbamoyl)phenyl]diazen-1-yl]naphthalene-2-carboxamide

Nanomaterial dustiness

Administrative data

Endpoint:

nanomaterial dustiness

Type of information:

experimental study

Adequacy of study:

key study

Study period:

18.09.2020 - 14.10.2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Remarks:

according to DIN EN 17199-3

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: EN 17199-3

Version / remarks:

measurement of dustiness of bulk materials that contain or release respirable NOAA or other
respirable particles - Part 3: Continuous drop method

GLP compliance:

no

Type of method:

continuous drop

Sampling:

The product was used without special pre-treatment, such as drying or similar.

Test material

Test material information

Constituent 1

Reference substance name:

Reference substance 001

Cas Number:

99402-80-9

Test material form:

solid: nanoform, no surface treatment

Results and discussion

Dustiness index

Dustiness index 1

Key result

Mean:

50 391 other: 1/mg

St. dev.:

0 other: not relevant

Remarks on result:

other:

Remarks:

dustiness index as number of airborne particles per mg in the nanoscale (10 nm - 100 nm)

Dustiness index 2

Mean:

13 301.3 other: N/cm3

St. dev.:

0 other: not relevant

Remarks on result:

other: number of airborne nanoparticles per cm3

Any other information on results incl. tables

Measurement duration: 10 min

temperature: 26°C, rel. air humidity 50 %

table 1: summary SMPS (sanning mobility particle sizer)

Range [nm]  Mean [nm]  Concentration [N/cm³] ICD [1/mg]   ECD [1/mg·s]  10-100 43,5 13301,3 50391,0 84,0  100-417 233,1 20347,7 77085,7 128,5  10-417 158,2 33649,0 127476,7 212,5

ICD: dustiness index as number of airborne particles per mg

ECD: emission rate as number of particles per mg per second

mean: average particle diameter in nm

N: number of airborne particles

table 2: summary OPS (optical particle sizer)

Range [µm]  Mean [µm]  Concentration [N/ cm3] ICD[1/mg]   ECD[1/mg x s]  0.3 - 10  5,4 394,0 1492,7 2,5

Applicant's summary and conclusion

Executive summary:

The dusting behaviour of the test material was investigated using DIN EN 17199 -3: 2019 -12 "workplace exposure - measurement of dustiness of bulk materials that contain or release respirable nano objects and their aggregates and agglomerates or other respirable particles- Part 3: Continuous drop method".

The dust released by the falling test material was measured by a scanning mobility particle sizer (SMPS,10 - 417 nm) and an optical particle sizer (3 - 10 µm). The counterflow was provided by cleaned, almost particle-free air.

The SMPS counted 13301.3 particles per cm3 in the nanoscale 10 - 100 nm. corresponding to a dustiness index of 50391.0 particles per mg in the nanoscale 10 - 100 nm. The mean size of the nanoparticles in the range 10 -100 nm was 43.5.

The OPS (0.3 - 10 µm) counted 394.0 particles per cm3 corresponding to a dustiness index of 1492.7 particles per mg. The mean size of the particles was 5.4 µm.