2,2-(1,4-phenylene)bis((4H-3,1-benzoxazine-4-one)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP - Guideline study

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Year:

1995

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2,2-(1,4-phenylene)bis((4H-3,1-benzoxazine-4-one)

EC Number:

418-280-1

EC Name:

2,2-(1,4-phenylene)bis((4H-3,1-benzoxazine-4-one)

Cas Number:

18600-59-4

Molecular formula:

C22H12N2O4

IUPAC Name:

2-[4-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-4H-3,1-benzoxazin-4-one

Test animals

Species:

other: rat, albino Sprague-Dawley

Administration / exposure

Vehicle:

other: Methocellulose

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Mortality:

Male: 5000 mg/kg bw; number of animals: 5; Number of deaths: 0
Female: 5000 mg/kg bw; number of animals: 5; Number of deaths: 0

Clinical signs:

other: Signs of toxicity related to dose levels; Signs seen on the day of dosing in a few animals included wet rales and soft stool. A few animals had decreased food consumption on the day of dosing; this continued in some animals through Day 2. One male had swo

Gross pathology:

Effects on organs:
Gross postmortemobservations were similar to those seen in historic controls.