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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP - Guideline study

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1995

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2-(1,4-phenylene)bis((4H-3,1-benzoxazine-4-one)
EC Number:
418-280-1
EC Name:
2,2-(1,4-phenylene)bis((4H-3,1-benzoxazine-4-one)
Cas Number:
18600-59-4
Molecular formula:
C22H12N2O4
IUPAC Name:
2-[4-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-4H-3,1-benzoxazin-4-one

Test animals

Species:
other: rat, albino Sprague-Dawley

Administration / exposure

Vehicle:
other: Methocellulose

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
Male: 5000 mg/kg bw; number of animals: 5; Number of deaths: 0
Female: 5000 mg/kg bw; number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels; Signs seen on the day of dosing in a few animals included wet rales and soft stool. A few animals had decreased food consumption on the day of dosing; this continued in some animals through Day 2. One male had swo
Gross pathology:
Effects on organs:
Gross postmortemobservations were similar to those seen in historic controls.

Applicant's summary and conclusion