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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP - Guideline study

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1995

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Consumer Product Safety Commission-FHSA-Federal Hazards Substances Regulation, 16 CFR 1500
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2-(1,4-phenylene)bis((4H-3,1-benzoxazine-4-one)
EC Number:
418-280-1
EC Name:
2,2-(1,4-phenylene)bis((4H-3,1-benzoxazine-4-one)
Cas Number:
18600-59-4
Molecular formula:
C22H12N2O4
IUPAC Name:
2-[4-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-4H-3,1-benzoxazin-4-one

Test animals

Species:
other: rabbit, albino New Zealand white
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: 0.9 % saline
Duration of exposure:
24 h
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 6; Number of deaths: 1
Female: 2000 mg/kg bw; Number of animals: 4; Number of feaths: 0
Gross pathology:
Signs of toxicity related to dose levels:
One male animals died on day 4 of the study. Most animals were free of significant signs of systemic toxicity on the day of dosing. On the day after dosing, most animals exhibited decreased food consumption, which continued in some animals through Day 5, or sporadically throughout the study.
Other findings:
Signs of toxicity (Local):
The test substance produced mild but transient dermal irritation. Most animals, at both the intact and abraded sites, exhibited very slight (barely perceptable) to slight erythema with little or no oedema. All irritation responses were resolved by Day 7.

Applicant's summary and conclusion