Registration Dossier

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP - Guideline study

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1995

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Consumer Product Safety Commission-FHSA-Federal Hazards Substances Regulations, 16 CFR 150
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2-(1,4-phenylene)bis((4H-3,1-benzoxazine-4-one)
EC Number:
418-280-1
EC Name:
2,2-(1,4-phenylene)bis((4H-3,1-benzoxazine-4-one)
Cas Number:
18600-59-4
Molecular formula:
C22H12N2O4
IUPAC Name:
2-[4-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-4H-3,1-benzoxazin-4-one
Details on test material:
Nature of substance: powder

Test animals / tissue source

Species:
other: rabbit, albino New Zealand white

Test system

Amount / concentration applied:
31.1 MG
Number of animals or in vitro replicates:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24/48/72 h
Score:
0.17
Max. score:
1
Remarks on result:
other: Max. duration: 72 h; Max. value at end of observation period: 0
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
0
Remarks on result:
other: Max. duration: 0 h; Max. value at end of observation period: 0
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
0
Remarks on result:
other: Max. duration: 0 h; Max. value at end of observation period: 0
Irritation parameter:
iris score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
0
Remarks on result:
other: Max. duration: 0 h; Max. value at end of observation period: 0
Irritant / corrosive response data:
Reversibility of any observed effect: Changes fully reversible within 3 days
Other effects:
None.

Applicant's summary and conclusion

Interpretation of results:
other: not classified