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EC number: 219-094-1 | CAS number: 2356-53-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 July 1987 to 13 August 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline-conform study under GLP.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1087
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane
- EC Number:
- 219-094-1
- EC Name:
- 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane
- Cas Number:
- 2356-53-8
- Molecular formula:
- C3Cl2F6O
- IUPAC Name:
- 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane
- Reference substance name:
- Methylic Adduct
- IUPAC Name:
- Methylic Adduct
- Details on test material:
- - Name of test material (as cited in study report): Ethane,1,2-dichloro-1,1,2-trifluoro-2-trifluoromethoxy
- Substance type: pure substance
- Physical state: liquid
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported
- Composition of test material, percentage of components: not reported
- Isomers composition: not reported
- Purity test date: not reported
- Lot/batch No.: F104206
- Expiration date of the lot/batch: not reported
- Stability under test conditions: not reported
- Storage condition of test material: in the dark under ambient conditions.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- Dose ranging study: 100, 500, 1000, 3000, 5000 mg/kg
Main study: 5000 mg/kg - No. of animals per sex per dose:
- Dose ranging study: 1 male and 1 female per dose
Main study: 5 males + 5 females at 5000 mg/kg - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- act. ingr.
Any other information on results incl. tables
Dose ranging
No deaths and no clinical signs were noted during the 14 day observation period.
Main study
There were no deaths.
Clinical signs were limited to piloerection noted at 1 -4 hours after dosing.
At post mortem, gross examination revealed no abnormalities.
Body weight gains are within the acceptable range.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP-Regulation (EC) No 1272/2008
- Conclusions:
- The median lethal dose (LD50) of 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane is greater than 5000 mg/kg bw.
- Executive summary:
The IRI project No.238237, includes an acute oral toxicity test, an eye irritation test and a dermal irritation test.
In the acute oral toxicity test in rats, no deaths occurred and mild transient clinical signs were noted following a single oral dose of
1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane at a dose level of 5000 mg/kg bw (vehicle: corn oil).
The median lethal dose (LD50) of 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane is greater than 5000 mg/kg bw.
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