Registration Dossier

Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report date:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
Reaction products of coconut oil with polyethyleneglycol and 2-ethyl-2-(hydroxymethyl)propane-1,3-diol
EC Number:
640-964-5
Cas Number:
218451-68-4
Molecular formula:
not applicable because UVCB
IUPAC Name:
Reaction products of coconut oil with polyethyleneglycol and 2-ethyl-2-(hydroxymethyl)propane-1,3-diol
Details on test material:
- Name of test material (as cited in study report): Marlowet 4753
- Physical state: cloudy white suspension with a viscosity similar to corn oil
- Lot/batch No.: S94505, Date Nov.19, 1999

Results and discussion

Solubility in organic solvents / fat solubility
Medium:
n-octanol
Solubility:
> 800 g/L
Temp.:
21 °C
Test substance stable:
yes
Details on results:
After mixing, the contents of the test tubes were clear homogeneous (single phase) solutions.
These results were consistent with octanol and test substance being miscible liquids at 21 °C.

Applicant's summary and conclusion

Conclusions:
The solubility of Coconut oil, reaction products with polyethylene glycol and trimethylolpropane in n-octanol was greater than 0.80 g/mL at 21 °C (< 800 g/L).
Executive summary:

The solubility of Coconut oil, reaction products with polyethylene glycol and trimethylolpropane in n-Octanol was tested according the preliminary test as indicated in OECD guideline 116 for the determination of fat solubility.

The solubility of Coconut oil, reaction products with polyethylene glycol and trimethylolpropane in n-octanol was greater than 0.80 g/mL at 21 °C (< 800 g/L).