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EC number: 640-964-5 | CAS number: 218451-68-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
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- Nanomaterial surface chemistry
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- Nanomaterial radical formation potential
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08/09-1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.8 (Toxicity for Earthworms: Artificial Soil Test)
- Principles of method if other than guideline:
- Toxizitaetstest fuer Regenwuermer in künstlichem Boden nach 88/302 EWG
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction products of coconut oil with polyethyleneglycol and 2-ethyl-2-(hydroxymethyl)propane-1,3-diol
- EC Number:
- 640-964-5
- Cas Number:
- 218451-68-4
- Molecular formula:
- not applicable because UVCB
- IUPAC Name:
- Reaction products of coconut oil with polyethyleneglycol and 2-ethyl-2-(hydroxymethyl)propane-1,3-diol
- Details on test material:
- - Name of test material (as cited in study report): Marlowet 4753
- Physical state: liquid, cristalline
- Stability under test conditions: > 1 year
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- no
- Details on preparation and application of test substrate:
- - Method of mixing into soil: The test substance was mixed with silica sand and afterwards added to soil substrate in a plastic bag. Water was added to a theoretical water content of approx. 40% and the substrate was thoroughly mixed
pH = 6
Test organisms
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Common name: earthworm
- Source: Eisenia GmbH&Co. Produktions- und Vertrieb KG, Kapellenstraße 25, Wiesbaden, Germany
- Age at test initiation: at least 2 months
- Weight at test initiation: average 350 mg (control), average 354 mg (test substance)
ACCLIMATION
- Acclimation period: not mentioned
Study design
- Study type:
- laboratory study
- Substrate type:
- other: peat and dried horse dung
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Post exposure observation period:
- no
Test conditions
- Test temperature:
- 20 +- 2 °C
- pH:
- 6
- Moisture:
- 40 %
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): Makrolon cages with perforated plexiglass covers, size not mentioned
- Amount of soil or substrate: not mentioned
- No. of organisms per container (treatment): 10
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
- Composition (if artificial substrate): mixture of peat and horse dung
- Organic carbon (%): not mentioned
- Maximum water holding capacity (in % dry weigth): 40 %
- CEC: not mentioned
- Pretreatment of soil: not mentioned
- Storage (condition, duration): fresh prepared
- Stability and homogeneity of test material in the medium: not mentioned
OTHER TEST CONDITIONS
- Photoperiod: 24 h
- Light intensity: approx. 400 lux
VEHICLE CONTROL PERFORMED: yes
TEST CONCENTRATIONS
- Spacing factor for test concentrations: not applicable, limit test
- Range finding study: not performed - Nominal and measured concentrations:
- not measured; nominal concentration 1000 mg/kg dry soil
- Reference substance (positive control):
- yes
- Remarks:
- chloracetamide, historical data
Results and discussion
Effect concentrations
- Key result
- Duration:
- 14 d
- Dose descriptor:
- LC10
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Mortality at end of exposure period: 1
- Total mass of adults at beginning of test: 14 g (test substance), 14.16 g (control), 40 adults each
- Changes in body weigth of live adults (% of initial weight) at end of exposure period: not mentioned
- No. of offspring produced: not mentioned
- No. of unhatched cocoons: not mentioned
- Morphological abnormalities: not mentioned
- Behavioural abnormalities: not mentioned
- Other biological observations: not mentioned - Results with reference substance (positive control):
- RESULTS: TEST WITH REFERENCE SUBSTANCE (historical data, from 1996-03-13 to 1996-03-27)
- Concentrations: 0, 10, 30 and 100 mg 2-chloroacetamide/kg dry soil
- Results (mortality): 0, 10, 30 mg/kg: 0/20 (0%) after 7 and 14 days, respectively; 100 mg/kg: 20/20 (100%) after 7 and 14 days, respectively.
Any other information on results incl. tables
RESULTS: EXPOSED
- Nominal concentrations: 1000 mg/kg dry soil
- Effect data (Mortality): 0/40 (0%) after 7 days; 1/40 (2.5%) after 14 days
RESULTS: CONTROL
- Effect data (Mortality): 0/40 (0%) after 7 and 14 days
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
In the toxicity limit test with Eisenia foetida foetida the test substance Marlowet 4753 (Coconut oil, reaction products with polyethylene glycol and trimethylolpropane) showed at a concentration of 1000 mg/kg (<= 10 %) no mortality after 7 and 14 days.
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