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Administrative data

Description of key information

Branched triamine C16-18 is corrosive to skin. Based on this, no studies on eye irritation need to be performed. 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Skin irritation

A study was performed to assess the irritancy potential of Branched triamine C16-18 to the skin of the New Zealand White rabbit. The method essentially followed OECD Test Guideline 404. Following a preliminary test, a single 3-min occluded application of the test material to the intact skin of three rabbits produced slight erythema immediately after patch removal. Necrotic lesions developed in all 3 animals after 3 days.

 

Eye irritation

In accordance with Column 2 of REACH Annex VII, the study does not need to be conducted, as the substance is corrosive to skin.

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Justification for classification or non-classification

Based on the results of the available in vivo skin irritation study showing a corrosive response following up to 3 min exposure but not yet observed after 1 hour, Branched triamine C16-18 needs to be classified as corrosive (C, R35, causes severe burns) according to DSD. In accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 as Corrosive Category 1B, H314 (causes severe burns and eye damage).

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