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Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
other information
Study period:
17-20 August 2009
Reliability:
1 (reliable without restriction)

Data source

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 201 (Alga, Growth Inhibition Test)
Qualifier:
according to guideline
Guideline:
ISO 8692 (Water Quality - Fresh Water Algal Growth Inhibition Test with Scenedesmus subspicatus and Selenastrum capricornutum)
Qualifier:
according to guideline
Guideline:
other: Guidance document on aquatic toxicity testing of difficult substances and mixtures, OECD series on testing and assessment number 23, December 14, 2000.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
(2E)-2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-({4-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}amino)prop-2-enamide; propan-2-ol
EC Number:
700-456-7
Cas Number:
1333490-26-8
Molecular formula:
C26H31Cl2N5O4 · 1/2(C3H8O1)
IUPAC Name:
(2E)-2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-({4-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}amino)prop-2-enamide; propan-2-ol
Details on test material:
Molecular formula C26H31Cl2N5O4
Molecular weight 548.46
Description Beige-yellow powder (determined at NOTOX)
Batch 09-002
Purity >92%
Composition 6.5% isopropanol as a hemi solvate

Test organisms

Test organisms (species):
Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Details on test organisms:
strain: NIVA CHL 1

Study design

Test type:
static
Water media type:
freshwater
Total exposure duration:
72 h

Results and discussion

Effect concentrations
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
ca. 0.007 mg/L
Details on results:
Due to the very low solubility of WAY-189172 in water, concentration levels that might be toxic for algae could not be reached

Any other information on results incl. tables

Under the conditions of the present study with Pseudokirchneriella subcapitata, no reduction of growth rate or inhibition of yield was recorded at any of the concentrations of WAY-189172 tested. The EC50 for growth rate reduction (ERC50: 0-72h) and yield inhibition (EYC50: 0-72h) were beyond the range tested, i.e. exceeded a TWA concentration of 0.007 mg/l. The NOEC for growth rate reduction and yield inhibition was 0.007 mg/l. Due to the very low solubility of WAY-189172 in water, concentration levels that might be toxic for algae could not be reached

Applicant's summary and conclusion

Conclusions:
The NOEC for growth rate reduction and yield inhibition was 0.007 mg/l. Due to the very low solubility of WAY-189172 in water, concentration levels that might be toxic for algae could not be reached